Age-dependent cutoffs for pathological brain volume loss

Estimates of age-dependent cutoffs for pathological brain volume loss using SIENA/FSLda longitudinal brain volumetry study in healthy adults

Brain volume loss (BVL) has gained increasing interest for monitoring tissue damage in neurodegenerative diseases including multiple sclerosis (MS). In this longitudinal study, 117 healthy participants (age range 37.3 82.6 years) received at least 2 magnetic resonance imaging examinations. BVL (in %) was determined with the Structural Image Evaluation using Normalisation of Atrophy/FMRIB Software Library and annualized. 2017.