NeuroQuant TBA 4.0: TBI Case Study

By Micki Maes

Sustaining any type of brain trauma can be very serious and there can be potential complications. Brain trauma is a risk factor for a variety of other brain-related problems, including chronic headaches, insomnia, and undiagnosed aneurysms. Magnetic resonance imaging (MRI) is one of the most sensitive diagnostic imaging tests available. This technology is useful for evaluating a wide range of brain disorders including traumatic injury, tumors, stroke, and aneurysms.

A special MRI scanning technique called diffusion tensor imaging (DTI) can be used to help diagnose aneurysms or other brain problems that may not appear on a routine MRI scan. A thorough assessment will include a NeuroQuant^® analysis, which is an advanced 3D volumetric post-processing software that automatically identifies and segments brain structures, measures their volumes, and compares the information to a normative database adjusted for age, gender, and cranial volume.

Emerging imaging technologies like MR spectroscopy (MRS) in TBI is being used to investigate changes in brain metabolites, such as reduced N-acetylaspartate (NAA) levels, which may demonstrate a loss of neuronal and axonal integrity.

Let’s take a closer look at this case study.

• Patient: Mya Pain
• DOB: 12/28/1972
• History: Brain trauma 10/10/2022
• Date of Exam: 3/24/23

Multi-Modal MRI Technique:

1. MRI Brain: MRI examination of the brain was performed on a Siemens Trio 3.0 Tesla scanner utilizing sagittal 3D 1.1 mm 3D ADNI, T2/FLAIR, with multiplanar reformation, axial fat sat T2, and axial 3D SWI.
2. NeuroQuant®: The 3D ADNI scan was analyzed by NeuroQuant® (Cortech’s Labs), a 3D morphometric technique utilizing an anatomic atlas based upon >3000 age (between 3 and 100 years) and gender-matched controls yielding percentile volume scores.
3. DTI Brain: Diffusion-tensor imaging (DTI) was performed on a Siemens Trio 3.0 Tesla scanner utilizing 30 directions with 5 mm sections, 1.5 mm gap, 230 mm field of view, TE/TR 106/3000 ms, two averages, AP phase, 128×128 matrix, 1.8 x 1.8 x 5.0 mm voxel size with 1/5mm slice gap, GRAPPA acceleration factor 2, 30 reference lines, b values of 0 s/mm2, and 2000 s/mm2, bw = 1396 Hz/Px and EPI factor of 128. 
4. 2D-CSI Spectroscopy (Chemical Shift Imaging):  2D-CSI spectroscopy of the centrum semiovale was performed on a Siemens Trio 3.0 Tesla scanner utilizing 16 voxels placed within the centrum semiovale centrally, oriented parallel to the Anterior-posterior commissure line, having voxel (ROI) dimensions of 15 mm3.  Sequence parameters were TE/TR 135 ms/1700 ms, with three averages; BW = 1200, vector size = 1024; width = 50; flip angle = 90 degrees; weak water suppression at 50 Hz, without spectral suppression.  ROIs within the centrum semiovale were analyzed in eight locations; the outer row of 4 ROIs centered within the midportion of each centrum semiovale were analyzed; the center two rows of ROIs positioned within the gray matter were not analyzed, yielding four ROIs on the right and four on the left, numbered front-to-back: Cho/Naa, Cr/Naa and Cho/Cr 1-4 and 5-8. 

Findings:

MRI Brain: Few abnormal foci of increased T2/FLAIR signal detected within the white matter. Orbits, sella and parasellar regions, pineal region, cerebellopontine angles and craniovertebral junction are unremarkable. No cyst, mass, or congenital anomaly detected. No abnormal fluid collection: no intracranial bleed of any age identified with particular attention to the SWI sequence. Sinuses are clear; no mastoid fluid. 

NeuroQuant TBA: Hippocampal volumes are at the 96th and 51st percentiles on the left and right respectively. Ventricular volume is at the 8th percentile. Global cortical gray matter volume is at the 58th percentile. Deep gray nuclei: left putamen 2nd percentile, right 7th percentile, left thalamus 1st percentile, right 57th percentile, left caudate 1st percentile, right 14th. Posterior cingulate gyrus left 1st percentile, right 3rd percentile. 

DTI Brain: Statistically significant FA reduction is present within the genu of the corpus callosum.

2D-CSI Spectroscopy (Chemical Shift Imaging): Statistically significant major metabolite ratio derangement is present.

Impressions:

• Statistically significant FA reduction on DTI analysis within the genu of the corpus callosum, most compatible with traumatic brain injury. 
• Statistically significant derangement of major metabolite ratios within the centrum semiovale most compatible with traumatic brain injury. 
• Clinical correlation is needed; follow-up multi-modal MRI examination including NeuroQuant^® and spectroscopy is recommended at clinically appropriate time.

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