Publications

Evidence-based validation that demonstrates how we continue to advance the field of neuroimaging

Examine detailed studies published in top medical journals that outline how physicians, radiologists, and researchers are using Cortechs.ai’s groundbreaking AI image analysis software to elevate diagnosis and treatment of neurodegenerative diseases and cancer.

Mesial Temporal Sclerosis: Accuracy Of NeuroQuant Versus Neuroradiologist

A study to compare the accuracy of a volumetric fully automated computer assessment of hippocampal volume asymmetry versus neuroradiologists’ interpretations of the temporal lobes for mesial temporal sclerosis (MTS), which is important for patients with temporal lobe epilepsy. American Journal of Neuroradiology, 2015 April 23.

Fully-automated Volumetric MRI With Normative Ranges- Translation To Clinical Practice

An article published in Behavioral Neurology (2009), “Fully-Automated volumetric MRI with Normative Ranges: Translation to Clinical Practice,” explains how NeuroQuant®’s fully-automated volumetric MRI capabilities with normative ranges can facilitate wider implementation of volumetric MRI beyond the academic setting.

Mild Cognitive Impairment: Baseline and Longitudinal Structural MR Imaging Measures Improve Predictive Prognosis

To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI). Radiology, June 2011.

Predicting MCI Outcome With Clinically Available MRI And CSF Biomarkers

Study to determine the ability of clinically available volumetric MRI (vMRI) and CSF biomarkers, alone or in combination with a quantitative learning measure, to predict conversion to Alzheimer’s disease (AD) in patients with mild cognitive impairment (MCI). 2011 October 12.

An Expanded Role For Neuroimaging In the Evaluation Of Memory Impairment

Authors Rahul Desikan et al from UCSD and UCSF describe a strategy to incorporate newly available imaging markers in the workup of memory problems, emphasizing that evidence of neurodegeneration can be an important piece of the puzzle to guide further management and testing, while helping to avoid overuse of more expensive biomarker tests. The paper highlights the way in which advanced neuroimaging tools such as Cortechs.ai’ NeuroQuant® volumetric MRI analysis system can provide information key to an improved understanding of the patient’s clinical status. (AJNR Am J Neuroradiology originally published online on June 13, 2013, 10.3174/ajnr.A3644)

Biomarkers For The Clinical Evaluation Of The Cognitively Impaired Elderly, Amyloid Is Not Enough

Recently published in the journal Imaging in Medicine (June, 2012), Linda K. McEvoy and James B. Brewer argue that while incorporating biomarkers for assessing Alzheimer’s disease risk (including volumetric MRI done with NeuroQuant®) can help in patient prognosis, tests for amyloid, if used in isolation, have potential for harm, as amyloid tests are clinically useful only when evidence suggests progressive cognitive decline or neurodegeneration. (Imaging in Medicine, June 2012, Vol. 4, No. 3 , Pages 343-357).

Structural Functional And Molecular Neuroimaging Biomarkers For Alzheimer’s Disease

Neuroimaging biomarkers are now routinely incorporated into AD clinical trials and are increasingly used in clinical practice. This paper broadly describes the development and use of these biomarkers as they relate to AD.

High-Throughput, Fully Automated Volumetry For Prediction Of MMSE And CDR Decline In Mild Cognitive Impairment

Scientists at the University of California, San Diego School of Medicine have shown that NeuroQuant®’s fully-automated volumetric MRI scanning is effective in predicting the progression from mild cognitive impairment (MCI) to Alzheimer’s disease. The procedure can be readily used in clinics to measure brain atrophy, and may help physicians to predict decline in MCI patients.

Fully-Automated Quantification Of Regional Brain Volumes For Improved Detection Of Focal Atrophy In Alzheimer’s Disease

NeuroQuant® Results Published in the American Journal of Neuroradiology.

Mesial Temporal Sclerosis: Accuracy Of NeuroQuant Versus Neuroradiologist

A study to compare the accuracy of a volumetric fully automated computer assessment of hippocampal volume asymmetry versus neuroradiologists’ interpretations of the temporal lobes for mesial temporal sclerosis (MTS), which is important for patients with temporal lobe epilepsy. American Journal of Neuroradiology, 2015 April 23.

Neuroradiology: Quantitative MR Volumetry In Temporal Lobe Epilepsy

Quantitative MR imaging using NeuroQuant® can enhance standard visual analysis, providing a viable means for translating volumetric analysis into clinical practice and increasing the detection of hippocampal atrophy in temporal lobe epilepsy in both community and tertiary care settings. Radiology August 2012 264:542-550; Published online June 21, 2012.

Amygdala Volume Changes In Posttraumatic Stress Disorder In A Large Case-Controlled Veterans Group

Assessment of military veterans with PTSD and trauma-exposed control subjects, with sufficient power to perform a definitive assessment of the effect of PTSD on volumetric changes in the amygdala and hippocampus and of the contribution of illness duration, trauma load, and depressive symptoms. November 2012.

Prospective Longitudinal MRI Study Of Brain Volumes And Diffusion Changes During The First Year After Moderate To Severe TBI

Prospective study of Traumatic Brain Injury (TBI) patients to investigate volume change in cortical grey matter (GM), hippocampus, lenticular nucleus, lobar white matter (WM), brainstem and ventricles.

Automated CT registration tool improves sensitivity to change in ventricular volume in patients with shunts and drains

A retrospective evaluation of ventricular shunt or EVD patients who underwent sequential head CT scans with an automated CT registration tool (CT CoPilot), assessing reader ability to discern change in ventricular volume between scans using standard axial CT images versus reformats and subtraction images generated by the registration tool. 2020.

Volumetric MR Imaging

Mesial Temporal Sclerosis: Accuracy Of NeuroQuant Versus Neuroradiologist

A study to compare the accuracy of a volumetric fully automated computer assessment of hippocampal volume asymmetry versus neuroradiologists’ interpretations of the temporal lobes for mesial temporal sclerosis (MTS), which is important for patients with temporal lobe epilepsy. American Journal of Neuroradiology, 2015 April 23.

Fully-automated Volumetric MRI With Normative Ranges- Translation To Clinical Practice

An article published in Behavioral Neurology (2009), “Fully-Automated volumetric MRI with Normative Ranges: Translation to Clinical Practice,” explains how NeuroQuant®’s fully-automated volumetric MRI capabilities with normative ranges can facilitate wider implementation of volumetric MRI beyond the academic setting.

Neurodementias

Mild Cognitive Impairment: Baseline and Longitudinal Structural MR Imaging Measures Improve Predictive Prognosis

To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI). Radiology, June 2011.

Predicting MCI Outcome With Clinically Available MRI And CSF Biomarkers

Study to determine the ability of clinically available volumetric MRI (vMRI) and CSF biomarkers, alone or in combination with a quantitative learning measure, to predict conversion to Alzheimer’s disease (AD) in patients with mild cognitive impairment (MCI). 2011 October 12.

An Expanded Role For Neuroimaging In the Evaluation Of Memory Impairment

Authors Rahul Desikan et al from UCSD and UCSF describe a strategy to incorporate newly available imaging markers in the workup of memory problems, emphasizing that evidence of neurodegeneration can be an important piece of the puzzle to guide further management and testing, while helping to avoid overuse of more expensive biomarker tests. The paper highlights the way in which advanced neuroimaging tools such as Cortechs.ai’ NeuroQuant® volumetric MRI analysis system can provide information key to an improved understanding of the patient’s clinical status. (AJNR Am J Neuroradiology originally published online on June 13, 2013, 10.3174/ajnr.A3644)

Biomarkers For The Clinical Evaluation Of The Cognitively Impaired Elderly, Amyloid Is Not Enough

Recently published in the journal Imaging in Medicine (June, 2012), Linda K. McEvoy and James B. Brewer argue that while incorporating biomarkers for assessing Alzheimer’s disease risk (including volumetric MRI done with NeuroQuant®) can help in patient prognosis, tests for amyloid, if used in isolation, have potential for harm, as amyloid tests are clinically useful only when evidence suggests progressive cognitive decline or neurodegeneration. (Imaging in Medicine, June 2012, Vol. 4, No. 3 , Pages 343-357).

Structural Functional And Molecular Neuroimaging Biomarkers For Alzheimer’s Disease

Neuroimaging biomarkers are now routinely incorporated into AD clinical trials and are increasingly used in clinical practice. This paper broadly describes the development and use of these biomarkers as they relate to AD.

High-Throughput, Fully Automated Volumetry For Prediction Of MMSE And CDR Decline In Mild Cognitive Impairment

Scientists at the University of California, San Diego School of Medicine have shown that NeuroQuant®’s fully-automated volumetric MRI scanning is effective in predicting the progression from mild cognitive impairment (MCI) to Alzheimer’s disease. The procedure can be readily used in clinics to measure brain atrophy, and may help physicians to predict decline in MCI patients.

Fully-Automated Quantification Of Regional Brain Volumes For Improved Detection Of Focal Atrophy In Alzheimer’s Disease

NeuroQuant® Results Published in the American Journal of Neuroradiology.

Epilepsy

Mesial Temporal Sclerosis: Accuracy Of NeuroQuant Versus Neuroradiologist

A study to compare the accuracy of a volumetric fully automated computer assessment of hippocampal volume asymmetry versus neuroradiologists’ interpretations of the temporal lobes for mesial temporal sclerosis (MTS), which is important for patients with temporal lobe epilepsy. American Journal of Neuroradiology, 2015 April 23.

Neuroradiology: Quantitative MR Volumetry In Temporal Lobe Epilepsy

Quantitative MR imaging using NeuroQuant® can enhance standard visual analysis, providing a viable means for translating volumetric analysis into clinical practice and increasing the detection of hippocampal atrophy in temporal lobe epilepsy in both community and tertiary care settings. Radiology August 2012 264:542-550; Published online June 21, 2012.

Traumatic Brain Injury

Amygdala Volume Changes In Posttraumatic Stress Disorder In A Large Case-Controlled Veterans Group

Assessment of military veterans with PTSD and trauma-exposed control subjects, with sufficient power to perform a definitive assessment of the effect of PTSD on volumetric changes in the amygdala and hippocampus and of the contribution of illness duration, trauma load, and depressive symptoms. November 2012.

Prospective Longitudinal MRI Study Of Brain Volumes And Diffusion Changes During The First Year After Moderate To Severe TBI

Prospective study of Traumatic Brain Injury (TBI) patients to investigate volume change in cortical grey matter (GM), hippocampus, lenticular nucleus, lobar white matter (WM), brainstem and ventricles.

Automated CT registration tool improves sensitivity to change in ventricular volume in patients with shunts and drains

A retrospective evaluation of ventricular shunt or EVD patients who underwent sequential head CT scans with an automated CT registration tool (CT CoPilot), assessing reader ability to discern change in ventricular volume between scans using standard axial CT images versus reformats and subtraction images generated by the registration tool. 2020.

Prostate Cancer